The article deals with the methods of teaching the discipline “Philosophy and methodology of science”, which is part of the master's program of higher education. The choice of this topic is due to the complexity of the subject, containing a large number of concepts and categories, various philosophical concepts and scientific theories, as well as the specifics of this cat-egory of students, many of whom are already established specialists. The aim of the work is to identify the most effective forms of teaching. Materials and methods of research were: author's experience of teaching and its system analysis; expe-rience of conducting classes in schools, adapted for teaching students; comparison and analogy; theoretical modeling of learning situations. The results of the study showed the effectiveness of forms of interactive learning. The content of the article includes: explanation of some methodological techniques to involve students in various forms of cognitive activity; description of the organization of student independent work; explanation of the main substantive aspects of the academic subject, which should be paid attention to when presenting the material at lectures and seminars. Interactive learning involves not only the teacher's dialogue with students, but also students with each other, joint discussion of problems, modeling of specific situations. Since the course content is associated with the understanding of the nature and structure of scientific knowledge, in the process of interactive learning a double reflection is carried out– the analysis of cognitive activity as it is and the students’ awareness of their own mental activity. The article shows the relationship between the educational material and the ways of forming interest and independent thinking in students. Further discussion will be held on such means of enhancing mental activity as the use of reference schemes and additional material, discussions and game forms of training. Interactive forms of training allow you to effectively master the course of philosophy and methodology of science and apply knowledge and skills in further research and professional activities.