The goal of the study. The goal of this empirical study is the analysis of the specific features of subjective per-ception by the residents living in the armed conflict area, of the significance of stress factors and their somatic health. This paper presents an analysis of the somatic and mental health of the respondents of the Donetsk People's Republic before and after the beginning of the armed conflict. Materials and methods. For the first time the article presents empirical data based on the developed by the author questionnaire titled “Determination of subjective perception of the significance of stress factors for the person living in an area of the armed conflict” the questions of which were grouped into the following blocks: threats to life, health, economic, socio-political, social, and psychological factors. The subjective assessment of the change in the somatic health of the residents was based on individual interviews, studying medical records on the nature and number of diseases in the last three years (from 2014 up to 2016). Results and their discussion. As a result of the research it was found that significant transformations took place in the somatic health of the respondents during the armed conflict. It was also established that changes in the somatic health are observed in both men and women; in men, the incidence of diseases is higher than that in women. It is empirically shown that in the areas of low-intensity shelling (ALIS) statistically significant are the influences of psychological, social and socio-political stress factors, whereas in the intensively shelled areas (ISA) the main factors affecting the human psyche are the threats to life, health and social factors. The author emphasizes the influence of stress factors on the age categories of people (from 35 to 60 years and from 60 to 75 years). Conclusion. Having studied the subjective assessments of somatic and mental health, and stress factors that affect the people living under the armed conflict conditions, it can be assumed that long stay of people in difficult life circumstances of an armed conflict can make it difficult to integrate them into society and demand corrective and re-adaptation measures, the development of which requires additional research and further implementation.